RealLine KRAS Detect

The RealLine KRAS Detect kit is designed for the detection of 7 mutations in codons 12 and 13 of the kRas gene by Real-Time PCR.

RUO – Research Use Only

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Description

Description

Colorectal cancer (mCRC) is the fourth most common cancer among men and women. About 40 % of mCRC patients have mutations of the KRAS gene in the tumor. Tumors with KRAS mutations in codons 12 or 13 are resistant to anti-EGFR therapy. Accordingly, treatment with drugs for the anti-EGFR therapy of mCRC like Erbitux® or Vectibix® is recommended only for tumors without such mutations.

Indications for Testing

Targeted therapy of metastatic colorectal cancer (mCRC).

Sample Material

  • Fresh tissue
  • Fresh-frozen tissue
  • Formalin fixed paraffin embedded (FFPE) tissue

Mutant codon – Nucleotides

  • G12C – TGT
  • G12S – AGT
  • G12R – CGT
  • G12V – GTT
  • G12D – GAT
  • G12A – GCT
  • G13D – GAC

IFU - MED20401_20403

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Additional information

Additional information

RealLine KRAS Detect RUO

12 Tests, 36 Tests

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