RealLine BRAF Detect V600E

RealLine BRAF Detect V600E kits are designed to detect missense mutation at codon 600 of the BRAF Gene in cancer tissue

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Description

Description

The RealLine BRAF Detect-V600E kit is designed to detect missense mutation GTG→GAG at Codon 600 of the BRAF gene which is associated with the sensitivity to the therapy with BRAF inhibitors.

BRAF, a serine-threonine kinase, is a member of the RAF protein kinase family. Activating mutations in BRAF were described in some cases of cancer like melanoma, papillary thyroid cancer, testicular, ovarian and colon cancers. About ~80 % of these somatic mutations is a missense mutation T1799A within the kinase domain of the BRAF that leads to change of Valine (Val) to Glutamic acid (Glu) at position 600 (V600E).
Selective inhibitors of BRAF – like Vemurafenib and Dabrafenib are used for the target therapy of melanoma which harbor BRAF-V600E mutation. Other compounds against tumors that carry the mutation BRAF-V600E are in clinical studies.

RealLine Cycler 48 or RealLine Cycler 96 (BIORON Diagnostics GmbH)

CFX96, iQ5 iCycler (Bio-Rad, USA)

DT96, DTLite (DNA-Technology, Russia)

Our kits can be used with other Real-Time cyclers from ABI, Roche, Agilent etc.
Please read the IFU properly and ask us for recommendations of device settings!

IFU - MED20701_20710

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Additional information

Additional information

RealLine BRAF Detect, V600E

12 Tests, 36 Tests

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